The title is a pun on the name of Kitty Pryde, the youngest of the X-Men by the time the pilot was produced. The series that this episode was intended to launch never materialized; Marvel Productions went back to the drawing board for 1992's X-Men: The Animated Series. The funding for the pilot was originally intended for a 13th episode of RoboCop: The Animated Series; Marvel Productions took advantage of this to have Toei Animation animate it. The pilot itself is most specifically influenced by issues #129–139 of Uncanny X-Men.
Shortly after this pilot was delivered, Marvel started having financial issues (New World Pictures, who purchased the Marvel Entertainment Group or MEG from Cadence Industries in 1986, sold MEG in January 1989 to the Andrews Group) and stopped work on every project in progress, except Muppet Babies. This pilot effectively marked the end of the Marvel animated universe created by DePatie–Freleng Enterprises/Marvel Productions, which began with Fantastic Four (1978) and continued with Spider-Woman (1979), Spider-Man (1981), Spider-Man and His Amazing Friends (1981) and The Incredible Hulk (1982). The X-Men themselves had previously guest starred in several episodes of Spider-Man and His Amazing Friends, although that particular series isn't necessarily in the same continuity as "Pryde of the X-Men".